The Belgium international pulled out of their Nations League squad and Pep Guardiola has confirmed he will miss the clash on Saturday
Kevin De Bruyne is set to miss the “next games” for Manchester City, but Sergio Aguero is in contention to face Arsenal on Saturday.
De Bruyne withdrew from the Belgium squad in midweek and City boss Pep Guardiola said he was not able to put a timescale on the midfielder’s return.
With a busy fixture schedule that sees City playing four Premier League and three Champions League matches in the next three weeks, any injury will be a significant setback.