The incident comes barely two weeks after a police officer and his family were also consumed by fire at Apromase in the Region.
It happened in the early hours of Wednesday, February 1.
The deceased have been identified as Abigail Manu, mother, 28, Norah Yeboah, 9, and Philipa Yeboah, 6.
There were emotions all over as charred bodies of the three were conveyed to the mortuary.
The cause of the fire has not been established but the Ghana National Fire Service has begun investigations into the matter.